In the midst of an elaborate con to settle a twenty-year old score, fortune hunter Nathan Drake stumbles into a centuries-old conspiracy that puts him back on the trail of his infamous ancestor, renowned explorer and privateer Sir Francis Drake.
But his search for a lost 16th-century treasure leads him to an even greater discovery -- an ancient secret that ensnares him in a web of deceit, pitting him against a shadowy clandestine organization and the occult treachery of its cunning and ruthless leader.
Aided by his partner and mentor Victor Sullivan, Drake embarks on a daring trek across Europe and into the Middle East, tracing the footsteps of the famed Lawrence of Arabia as they follow a centuries-old trail of clues leading to a fabled lost city buried for millennia in the heart of Arabia's Rub' al-Khali desert -- a legend Lawrence christened "the Atlantis of the Sands."
But the vast and pitiless wasteland of the Empty Quarter conceals a terrible mystery, and before the end of their journey, the race to unearth the wealth of the lost city descends into a desperate bid for survival, an ordeal that will push Drake to the limits of his endurance and force him to confront his deepest fears.